Conceptual schema-centric development (CSCD) is a research goal that reformulates the historical aim of automating 
information systems development. In CSCD, conceptual schemas would be explicit, executable in the production environment 
and the basis for the system’s evolution. To achieve the CSCD goal, several research problems must be solved. 
In this paper we identify and comment on sixteen problems that should be included in a research agenda for CSCD.